产品货号：
Z30722
中文名称：
SCUBE3抗体
英文名称：
Anti-SCUBE3 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SCUBE3 Antibody |
| 指标别名 | CEGF3;SCUBE3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IF |
| 基因名称 | SCUBE3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | SCUBE3 antibody was raised against a 15 amino acid synthetic peptide near the center of human SCUBE3.The immunogen is located within amino acids 210 - 260 of SCUBE3. |
| 计算分子量 | 109kDa |
| 成分 | SCUBE3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | SCUBE3 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones,and to a lesser extent in heart.Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy,suggesting that it may also play a role in the regulation of cardiac growth..SCUBE3 has been shown to be an endogenous TGF-汕receptor ligand and is thought to promote lung cancer cell mobility and invasiveness.In lung cancer cells,the secreted SCUBE3 protein was cleaved by MMP2 and MMP9,allowing the activation of the TGF-汕receptor,the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-汕1,VEGF,Snail,and Slug. |
| Uniprot ID | Q8IX30 |
| 基因名全称 | Signal peptide,CUB and EGF-like domain-containing protein 3 precursor |
| 蛋白名全称 | Signal peptide,CUB and EGF-like domain-containing protein 3 precursor |
| 推荐稀释比 | SCUBE3 antibody can be used for detection of SCUBE3 by Western blot at 1 ～ 2μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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